For the 2025-26 school year, there are 3 public high schools serving 637 students in Mississippi County, MO.
The top-ranked public high schools in Mississippi County, MO are East Prairie High School and Charleston High School. Overall testing rank is based on a school's combined math and reading proficiency test score ranking.
Mississippi County, MO public high schools have an average math proficiency score of 15% (versus the Missouri public high school average of 36%), and reading proficiency score of 39% (versus the 51% statewide average). High schools in Mississippi County have an average ranking of 1/10, which is in the bottom 50% of Missouri public high schools.
Mississippi County, MO public high school have a Graduation Rate of 91%, which is more than the Missouri average of 89%.
The school with highest graduation rate is East Prairie High School, with 90-94% graduation rate. Read more about public school graduation rate statistics in Missouri or national school graduation rate statistics.
Minority enrollment is 43% of the student body (majority Black), which is more than the Missouri public high school average of 30% (majority Black).
Best Public High Schools in Mississippi County (2025-26)
School
(Math and Reading Proficiency)
(Math and Reading Proficiency)
Location
Quick Facts
Rank: #11.
East Prairie High School
(Math: 20-29% | Reading: 40-44%)
Rank:
Rank:
4/
Bottom 50%10
304 E Walnut
East Prairie, MO 63845
(573) 649-3564
East Prairie, MO 63845
(573) 649-3564
Gr: 9-12 | 306 students Student-teacher ratio: 13:1 Minority enrollment: 12%
Rank: #22.
Charleston High School
(Math: 10-14% | Reading: 30-39%)
Rank:
Rank:
2/
Bottom 50%10
606 S. Thorn St
Charleston, MO 63834
(573) 683-3761
Charleston, MO 63834
(573) 683-3761
Gr: 7-12 | 331 students Student-teacher ratio: 12:1 Minority enrollment: 72%
Rank: n/an/a
Southeast Correctional Center
Alternative School
300 E Pedro Simmons Dr
Charleston, MO 63834
(573) 683-4409
Charleston, MO 63834
(573) 683-4409
Gr: 7-12
Mississippi County Public Schools (Closed)
School
Location
Quick Facts
510 Wilkinson
East Prairie, MO 63845
(573) 649-3521
East Prairie, MO 63845
(573) 649-3521
Gr: 3-6
711 E Commercial St
Charleston, MO 63834
(573) 683-3913
Charleston, MO 63834
(573) 683-3913
Gr: K | 92 students Student-teacher ratio: 12:1 Minority enrollment: 66%
210 E Washington
East Prairie, MO 63845
(573) 649-9368
East Prairie, MO 63845
(573) 649-9368
Gr: 7-8
402 Washington
East Prairie, MO 63845
(573) 649-2272
East Prairie, MO 63845
(573) 649-2272
Gr: PK-2
Frequently Asked Questions
What are the top-ranked public high schools in Mississippi County, MO?
The top-ranked public high schools in Mississippi County, MO include East Prairie High School and Charleston High School.
How many public high schools are located in Mississippi County?
3 public high schools are located in Mississippi County.
What is the racial composition of students in Mississippi County?
Mississippi County public high schools minority enrollment is 43% of the student body (majority Black), which is more than the Missouri public high schools average of 30% (majority Black).
Which public high schools in Mississippi County are often viewed compared to one another?
Popular comparisons of public high schools in Mississippi County include: East Prairie High School vs. Charleston High School, Charleston High School vs. East Prairie High School
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