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For the 2025-26 school year, there are 6 public schools serving 3,469 students in Florence, MS (there are , serving 362 private students). 91% of all K-12 students in Florence, MS are educated in public schools (compared to the MS state average of 89%).

The top-ranked public schools in Florence, MS are Florence Elementary School, Florence Middle School and Mclaurin Attendance Center. Overall testing rank is based on a school's combined math and reading proficiency test score ranking.

Florence, MS public schools have an average math proficiency score of 67% (versus the Mississippi public school average of 53%), and reading proficiency score of 56% (versus the 42% statewide average). Schools in Florence have an average ranking of 9/10, which is in the top 20% of Mississippi public schools.

Minority enrollment is 23% of the student body (majority Black), which is less than the Mississippi public school average of 58% (majority Black).