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For the 2025-26 school year, there are 4 public schools serving 2,247 students in Depew, NY (there are , serving 602 private students). 79% of all K-12 students in Depew, NY are educated in public schools (compared to the NY state average of 85%).

The top-ranked public schools in Depew, NY are Depew High School, John A Sciole Elementary School and Depew Middle School. Overall testing rank is based on a school's combined math and reading proficiency test score ranking.

Depew, NY public schools have an average math proficiency score of 51% (versus the New York public school average of 52%), and reading proficiency score of 36% (versus the 49% statewide average). Schools in Depew have an average ranking of 3/10, which is in the bottom 50% of New York public schools.

Minority enrollment is 19% of the student body (majority Hispanic and Asian), which is less than the New York public school average of 60% (majority Hispanic).